Schnell, Oliver, Cappuccio, Francesco, Genovese, Stefano, Standl, E. (Eberhard), Valensi, Paul and Ceriello, Antonio (2013) Type 1 diabetes and cardiovascular disease. Cardiovascular Diabetology, Volume 12 (Number 1). p. 156. doi:10.1186/1475-2840-12-156 ISSN 1475-2840.

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Abstract

The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor of both micro- and macrovascular complications. In Type 1 diabetes, the presence of coronary calcifications is also related to coronary artery disease. Cardiac autonomic neuropathy, which significantly impairs myocardial function and blood flow, also enhances cardiac abnormalities. Also hypoglycemic episodes are considered to adversely influence cardiac performance. Intensive insulin therapy has been demonstrated to reduce the occurrence and progression of both micro- and macrovascular complications. This has been evidenced by the Diabetes Control and Complications Trial (DCCT) / Epidemiology of Diabetes Interventions and Complications (EDIC) study. The concept of a metabolic memory emerged based on the results of the study, which established that intensified insulin therapy is the standard of treatment of Type 1 diabetes. Future therapies may also include glucagon-like peptide (GLP)-based treatment therapies. Pilot studies with GLP-1-analogues have been shown to reduce insulin requirements.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Diabetes, Diabetes -- Complications , Cardiovascular system -- Diseases , Hyperglycemia , Diabetes -- Research
Journal or Publication Title:	Cardiovascular Diabetology
Publisher:	Biomed central
ISSN:	1475-2840
Official Date:	2013
Dates:	Date Event 2013 Published
Volume:	Volume 12
Number:	Number 1
Page Range:	p. 156
DOI:	10.1186/1475-2840-12-156
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	26 December 2015
Date of first compliant Open Access:	26 December 2015

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