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The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy
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Kajihara, T., Brosens, Jan J. and Ishihara, Osamu (2013) The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy. Medical Molecular Morphology, Volume 46 (Number 2). pp. 61-68. doi:10.1007/s00795-013-0018-z
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Official URL: http://dx.doi.org/10.1007/s00795-013-0018-z
Abstract
Successful pregnancy requires coordination of embryo development, decidualization of endometrium, and placenta formation. Decidualization denotes the transformation of endometrial stromal cells into specialized secretory cells, a process further characterized with influx of specialized immune cells into stroma, predominantly uterine natural killer cells and macrophages, and vascular remodeling. This differentiation process depends on the convergence of the cyclic adenosine monophosphate and progesterone signaling pathways. The decidual process is indispensable for the formation of a functional feto-maternal interface as it controls tissue homeostasis during endovascular trophoblast invasion and bestows tissue resistance to environmental stress signals, including protection against oxidative cell death. FOXO proteins have emerged as key mediators of cell fate because of their ability to regulate either pro-apoptotic genes or genes involved in differentiation, cell cycle arrest, oxidative defenses, and DNA repair. In the endometrium, FOXO1 is of particular importance as a critical regulator of progesterone-dependent differentiation, menstrual shedding, and protection of the feto-maternal against oxidative damage during pregnancy.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Endometrium, Decidua, Forkhead transcription factors, Pregnancy -- Trimester, First, Reproductive health, Clinical medicine | ||||
| Journal or Publication Title: | Medical Molecular Morphology | ||||
| Publisher: | Springer Japan KK | ||||
| ISSN: | 1860-1480 | ||||
| Official Date: | June 2013 | ||||
| Dates: |
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| Volume: | Volume 46 | ||||
| Number: | Number 2 | ||||
| Page Range: | pp. 61-68 | ||||
| DOI: | 10.1007/s00795-013-0018-z | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Japan. Monbushō, Saitama Ika Daigaku | ||||
| Grant number: | 23592412 (Monbushō), 10-08 (SID) |
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