The Library
Genetics of the connectome
Tools
Tools
Tools
Thompson, Paul M., Ge, Tian, Glahn, David C., Jahanshad, Neda and Nichols, Thomas E. (2013) Genetics of the connectome. NeuroImage, Volume 80 . pp. 475-488. doi:10.1016/j.neuroimage.2013.05.013 ISSN 1053-8119.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.neuroimage.2013.05.013
Abstract
Connectome genetics attempts to discover how genetic factors affect brain connectivity. Here we review a variety of genetic analysis methods-such as genome-wide association studies (GWAS), linkage and candidate gene studies-that have been fruitfully adapted to imaging data to implicate specific variants in the genome for brain-related traits. Studies that emphasized the genetic influences on brain connectivity. Some of these analyses of brain integrity and connectivity using diffusion MRI, and others have mapped genetic effects on functional networks using resting state functional MRI. Connectome-wide genome-wide scans have also been conducted, and we review the multivariate methods required to handle the extremely high dimension of the genomic and network data. We also review some consortium efforts, such as ENIGMA, that offer the power to detect robust common genetic associations using phenotypic harmonization procedures and meta-analysis. Current work on connectome genetics is advancing on many fronts and promises to shed light on how disease risk genes affect the brain. It is already discovering new genetic loci and even entire genetic networks that affect brain organization and connectivity.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Science > Statistics |
||||
| Journal or Publication Title: | NeuroImage | ||||
| Publisher: | Elsevier | ||||
| ISSN: | 1053-8119 | ||||
| Official Date: | 15 October 2013 | ||||
| Dates: |
|
||||
| Volume: | Volume 80 | ||||
| Page Range: | pp. 475-488 | ||||
| DOI: | 10.1016/j.neuroimage.2013.05.013 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
