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Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers
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Filippov, Andrei and Antzutkin, Oleg N. (2013) Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers. Mendeleev Communications, Volume 23 (Number 6). pp. 316-318. doi:10.1016/j.mencom.2013.11.003 ISSN 0959-9436.
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Official URL: http://dx.doi.org/10.1016/j.mencom.2013.11.003
Abstract
For the first time effect of added Alzheimer´s Abeta(1-40) peptide of wild type on lateral diffusion of lipids in macroscopically oriented bilayers of “raft” compositions (mixture of dioleoylphosphatidylcholine (DOPC), sphingomielin (SM) and cholesterol (CHOL)) was studied by NMR-diffusion technique. In homogeneous bilayers diffusion coefficients decrease, while in liquid ordered and in liquid disordered phases they change differently at varied concentrations of CHOL that was explained by decreased maximum solubility of CHOL in phospholipids in the presence of Abeta(1-40) peptide.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Journal or Publication Title: | Mendeleev Communications | ||||
Publisher: | Elsevier BV | ||||
ISSN: | 0959-9436 | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | Volume 23 | ||||
Number: | Number 6 | ||||
Page Range: | pp. 316-318 | ||||
DOI: | 10.1016/j.mencom.2013.11.003 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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