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Vitamin D supplementation as an adjuvant therapy for patients with T2DM : an 18-month prospective interventional study
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Al-Daghri, Nasser M., Alkharfy, Khalid M., Al-Othman, Abdulaziz, El-Kholie, Emad, Moharram, Osama, Alokail, Majed S., Al-Saleh, Yousef, Sabico, Shaun, Kumar, Sudhesh and Chrousos, George P. (2012) Vitamin D supplementation as an adjuvant therapy for patients with T2DM : an 18-month prospective interventional study. Cardiovascular Diabetology, Volume 11 (Number 1). Article number 85. doi:10.1186/1475-2840-11-85
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Official URL: http://dx.doi.org/10.1186/1475-2840-11-85
Abstract
Background
Vitamin D deficiency has been associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2 (T2DM). In this prospective interventional study we investigated the effects of vitamin D3 supplementation on the metabolic profiles of Saudi T2DM subjects pre- and post-vitamin D supplementation over an 18-month period.
Methods
T2DM Saudi subjects (men, N = 34: Age: 56.6 ± 8.7 yr, BMI, 29.1 ± 3.3 kg/m2; women, N = 58: Age: 51.2 ± 10.6 yr, BMI 34.3 ± 4.9 kg/m2;) were recruited and given 2000 IU vitamin D3 daily for 18 months. Anthropometrics and fasting blood were collected (0, 6, 12, 18 months) to monitor serum 25-hydroxyvitamin D using specific ELISA, and to determine metabolic profiles by standard methods.
Results
In all subjects there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (32.2 ± 1.5 nmol/L) to 18 months (54.7 ± 1.5 nmol/L; p < 0.001), as well as serum calcium (baseline = 2.3 ± 0.23 mmol/L vs. 18 months = 2.6 ± 0.1 mmol/L; p = 0.003). A significant decrease in LDL- (baseline = 4.4 ± 0.8 mmol/L vs. 18 months = 3.6 ± 0.8 mmol/L, p < 0.001] and total cholesterol (baseline = 5.4 ± 0.2 mmol/L vs. 18 months = 4.9 ± 0.3 mmol/L, p < 0.001) were noted, as well as a significant improvement in HOMA-β function ( p = 0.002). Majority of the improvements elicited were more prominent in women than men.
Conclusion
In the Saudi T2DM population receiving oral Vitamin D3 supplementation (2000 IU/day), circulating 25-hydroxyvitamin D levels remained below normal 18 months after the onset of treatment. Yet, this “suboptimal” supplementation significantly improved lipid profile with a favorable change in HDL/LDL ratio, and HOMA-β function, which were more pronounced in T2DM females.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Library of Congress Subject Headings (LCSH): | Non-insulin-dependent diabetes -- Treatment, Cholecalciferol -- Therapeutic use, Vitamin D -- Therapeutic use | ||||
| Journal or Publication Title: | Cardiovascular Diabetology | ||||
| Publisher: | Biomed Central | ||||
| ISSN: | 1475-2840 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Volume 11 | ||||
| Number: | Number 1 | ||||
| Article Number: | Article number 85 | ||||
| DOI: | 10.1186/1475-2840-11-85 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | Madīnat al-Malik ʻAbd al-ʻAzīz lil-ʻUlūm wa-al-Tiqnīyah [King Abdulaziz City for Science and Technology] (KACST) | ||||
| Grant number: | AT-29-38 (KACST) |
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