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Obesity in kidney transplantation
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Chan, Winnie, Bosch, Jos A., Jones, David, McTernan, P. G., Phillips, Anna C. and Borrows, Richard (2014) Obesity in kidney transplantation. Journal of Renal Nutrition, Volume 24 (Number 1). pp. 1-12. doi:10.1053/j.jrn.2013.09.002 ISSN 1051-2276.
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Official URL: http://dx.doi.org/10.1053/j.jrn.2013.09.002
Abstract
Kidney transplantation is the preferred modality of renal replacement therapy. Long-term patient and graft survival have only improved marginally over the recent decade, mainly because of the development of cardiovascular disease after transplantation. Obesity is a risk factor for cardiovascular disease and is common before and after transplantation. This article reviews the literature assessing the role of pre- and post-transplant obesity on patient and graft survival, discusses the underlying obesity-related mechanisms leading to inferior kidney transplant outcomes, and explores the role of nutritional intervention on improving long-term outcomes of transplantation. Although the role of pretransplant obesity remains uncertain, post-transplant obesity increases the risk of graft failure and mortality. Nutritional intervention is effective in achieving post-transplant weight loss, but the effect on long-term outcomes has not been established. Future research should focus on conducting nutritional intervention studies aiming to improve long-term outcomes of kidney transplantation
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Journal of Renal Nutrition | ||||
Publisher: | W.B. Saunders Co. | ||||
ISSN: | 1051-2276 | ||||
Official Date: | 2014 | ||||
Dates: |
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Volume: | Volume 24 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 1-12 | ||||
DOI: | 10.1053/j.jrn.2013.09.002 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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