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Integrating medicinal plants extraction into a high-value biorefinery : an example of Artemisia annua L.
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Lapkin, Alexei, Adou, Eba, Mlambo, Benhilda N., Chemat, Smain, Suberu, John O., Collis, Alana E. C., Clark, Andrew J. and Barker, Guy C. (2014) Integrating medicinal plants extraction into a high-value biorefinery : an example of Artemisia annua L. Comptes Rendus Chimie, 17 (3). pp. 232-241. doi:10.1016/j.crci.2013.10.023 ISSN 1631-0748.
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Official URL: http://dx.doi.org/10.1016/j.crci.2013.10.023
Abstract
A principle of biorefining is extended to medicinal plants with the view of developing a more sustainable business model for biomass producers and extractors. This is demonstrated for Artemisia annua L. currently cultivated or harvested in the wild for extraction of a single compound, artemisinin, comprising on average 1 wt% dry weight of the plant biomass. We scaled extraction of artemisinin by a non-toxic to bacterial fermentation solvent tetrafluoroethane to a 5 L pilot scale. We identified a number of co-metabolites that could be extracted from the plant along with artemisinin and describe the multi-step extraction-fractionation sequence that potentially could be transferred to a large-scale multi-step extraction process. We also show possible routes to higher-value compounds on the basis of A. annua secondary metabolites, exemplified by the conversion of flavonoids to monomers.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Journal or Publication Title: | Comptes Rendus Chimie | ||||||||
| Publisher: | Elsevier Masson | ||||||||
| ISSN: | 1631-0748 | ||||||||
| Official Date: | March 2014 | ||||||||
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| Volume: | 17 | ||||||||
| Number: | 3 | ||||||||
| Page Range: | pp. 232-241 | ||||||||
| DOI: | 10.1016/j.crci.2013.10.023 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
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