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Nonautonomous movement of chromosomes in mitosis

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Vladimirou, Elina , Mchedlishvili, Nunu, Gasic, Ivana, Armond, Jonathan W., Samora, Catarina P., Meraldi, Patrick and McAinsh, Andrew D. (2013) Nonautonomous movement of chromosomes in mitosis. Developmental Cell, Volume 27 (Number 1). pp. 60-71. doi:10.1016/j.devcel.2013.08.004 ISSN 1534-5807.

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Official URL: http://dx.doi.org/10.1016/j.devcel.2013.08.004

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Abstract

Kinetochores are the central force-generating machines that move chromosomes during cell division. It is generally assumed that kinetochores move in an autonomous manner. However, we reveal here that movements of neighboring sister-kinetochore pairs in metaphase are correlated in a distance-dependent manner. This correlation increases in the absence of kinetochore oscillations or stable end-on attachments. This suggests that periodic movements of bioriented chromosomes limit the correlated motion of nonsisters. Computer simulations show that these correlated movements can occur when elastic crosslinks are placed between the K-fibers of oscillating kinetochores. Strikingly, inhibition of the microtubule crosslinking motor kinesin-5 Eg5 leads to an increase in nonsister correlation and impairs periodic oscillations. These phenotypes are partially rescued by codepletion of the kinesin-12 Kif15, demonstrating a function for kinesin-5 and kinesin-12 motors in driving chromosome movements, possibly as part of a crosslinking structure that correlates the movements of nonsister kinetochores.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Developmental Cell
Publisher: Cell Press
ISSN: 1534-5807
Official Date: 14 October 2013
Dates:
DateEvent
14 October 2013Published
Volume: Volume 27
Number: Number 1
Page Range: pp. 60-71
DOI: 10.1016/j.devcel.2013.08.004
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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