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Small ubiquitin-like modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin
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Conti, Lucio, Nelis, Stuart, Zhang, Cunjin, Woodcock, Ailidh, Swarup, Ranjan, Galbiati, Massimo, Tonelli, Chiara, Napier, R., Hedden, Peter, Bennett, Malcolm J. and Sadanandom, Ari (2014) Small ubiquitin-like modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin. Developmental Cell, Volume 28 (Number 1). pp. 102-110. doi:10.1016/j.devcel.2013.12.004 ISSN 1534-5807.
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WRAP_Napier__0380026-lf-290114-developmental-cell-conti_et_al.pdf - Accepted Version Download (2543Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.devcel.2013.12.004
Abstract
Plants survive adverse conditions by modulating their growth in response to a changing environment. Gibberellins (GAs) play a key role in these adaptive responses by stimulating the degradation of growth-repressing DELLA proteins. GA binding to its receptor GID1 enables association of GID1 with DELLAs. This leads to the ubiquitin-mediated proteasomal degradation of DELLAs and consequently growth promotion. We report that DELLA-dependent growth control can be regulated independently of GA. We demonstrate that when a proportion of DELLAs is conjugated to the Small Ubiquitin-like Modifier (SUMO) protein, the extent of conjugation increases during stress. We identify a SUMO-interacting motif in GID1 and demonstrate that SUMO-conjugated DELLA binds to this motif in a GA-independent manner. The consequent sequestration of GID1 by SUMO-conjugated DELLAs leads to an accumulation of non-SUMOylated DELLAs, resulting in beneficial growth restraint during stress. We conclude that plants have developed a GA-independent mechanism to control growth.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Gibberellic acid , Gibberellins , Plant hormones , Growth (Plants) -- Molecular aspects | ||||
Journal or Publication Title: | Developmental Cell | ||||
Publisher: | Cell Press | ||||
ISSN: | 1534-5807 | ||||
Official Date: | 13 January 2014 | ||||
Dates: |
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Volume: | Volume 28 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 102-110 | ||||
DOI: | 10.1016/j.devcel.2013.12.004 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 26 December 2015 | ||||
Date of first compliant Open Access: | 26 December 2015 | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Università di Milano , Leverhulme Trust (LT), Fondazione Umberto Veronesi [Umberto Veronesi Foundation], Italy. Ministero dell'istruzione, dell'università e della ricerca (MIUR) | ||||
Grant number: | 2010-2011 prot. 2010HEBBB8_006 (MIUR) |
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