The Library
A comparison of patient and tumour characteristics in two UK bladder cancer cohorts separated by 20 years
Tools
Bryan, Richard T., Zeegers, Maurice P., van Roekel, Eline H., Bird, Deborah, Grant, Margaret R., Dunn, Janet A., Bathers, Sarah, Iqbal, Gulnaz, Khan, Humera S., Collins, Stuart I., Howman, Andrew, Deshmukh, Nayneeta S., James, Nicholas D., Cheng, Kar Keung and Wallace, D. Michael A. (2013) A comparison of patient and tumour characteristics in two UK bladder cancer cohorts separated by 20 years. BJU International, Volume 112 (Number 2). pp. 169-175. doi:10.1111/bju.12032 ISSN 1464-4096.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1111/bju.12032
Abstract
Objectives To compare patient and tumour characteristics at presentation from two large bladder cancer cohorts, with recruitment separated by 15-20 years To identify significant differences in the West Midlands' urothelial cancer of the bladder (UCB) population during this period. Patients and Methods Data were collected prospectively from 1478 patients newly diagnosed with UCB in the West Midlands from January 1991 to June 1992 (Cohort 1), and from 1168 patients newly diagnosed with UBC within the same region from December 2005 to April 2011 (Cohort 2). Gender, age, smoking history, and tumour grade, stage, type, multiplicity and size at presentation were compared using a Pearson chi-square test or Cochran-Armitage trend test, as appropriate. Result Cohort 2 had a higher proportion of male patients (P = 0.021), elderly patients (P < 0.001), grade 3 tumours (P < 0.001), Ta/T1 tumours (P = 0.008), multiple tumours (P < 0.001), and tumours of ≤2 cm in diameter (P < 0.001). Conclusions There were significant differences between the cohorts. These differences are potentially explained by an ageing population, changes in grading practices, improved awareness of important symptoms, improved cystoscopic technology, and reductions in treatment delays. Regional cohorts remain important for identifying changes in tumour and patient characteristics that may influence disease management in the UK and beyond.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | BJU International | ||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
ISSN: | 1464-4096 | ||||
Official Date: | July 2013 | ||||
Dates: |
|
||||
Volume: | Volume 112 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 169-175 | ||||
DOI: | 10.1111/bju.12032 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |