Truong, Vinh X., Ablett, Matthew P., Gilbert, Hamish T. J., Bowen, James, Richardson, Stephen M., Hoyland, Judith A. and Dove, Andrew P. (2014) In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering. Biomaterials Science, Volume 2 (Number 2). pp. 167-175. doi:10.1039/c3bm60159e ISSN 2047-4830.

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Abstract

A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5–60 min at 37 °C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Journal or Publication Title:	Biomaterials Science
Publisher:	R S C Publications
ISSN:	2047-4830
Official Date:	2014
Dates:	Date Event 2014 Published
Volume:	Volume 2
Number:	Number 2
Page Range:	pp. 167-175
DOI:	10.1039/c3bm60159e
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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