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Metallothioneins : unparalleled diversity in structures and functions for metal ion homeostasis and more
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Blindauer, Claudia A. and Leszczyszyn, Oksana I. (2010) Metallothioneins : unparalleled diversity in structures and functions for metal ion homeostasis and more. Natural Product Reports, Vol.27 (No.5). pp. 720-741. ISSN 0265-0568
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Official URL: http://dx.doi.org/10.1039/b906685n
Abstract
Metallothioneins have been the subject of intense study for five decades, and have greatly inspired the development of bio-analytical methodologies including multi-dimensional and multi-nuclear NMR. With further advancements in molecular biology, protein science, and instrumental techniques, recent years have seen a renaissance of research into metallothioneins. The current report focuses on in vitro studies of so-called class II metallothioneins from a variety of phyla, highlighting the diversity of metallothioneins in terms of structure, biological functions, and molecular functions such as metal ion specificity, thermodynamic stabilities, and kinetic reactivity. We are still far from being able to predict any of these properties, and further efforts will be required to generate the knowledge that will enable a better understanding of what governs the biological and chemical properties of these unusual and intriguing small proteins.
| Item Type: | Journal Item |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Metallothionein, Metal ions, Homeostasis, Speciation (Chemistry) |
| Journal or Publication Title: | Natural Product Reports |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 0265-0568 |
| Official Date: | 2010 |
| Volume: | Vol.27 |
| Number: | No.5 |
| Number of Pages: | 22 |
| Page Range: | pp. 720-741 |
| Identification Number: | 10.1039/b906685n |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Funder: | Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation], Novartis Foundation, Natural Environment Research Council (Great Britain), European Commission, Wellcome Trust (London, England) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/5933 |
Data sourced from Thomson Reuters' Web of Knowledge
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