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The calcium-sensing receptor and beta-cell function
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Squires, Paul E., Jones, Peter J., Younis, Mustafa Y. G. and Hills, Claire E. (2014) The calcium-sensing receptor and beta-cell function. In: Litwack, Gerald, (ed.) The Pancreatic beta-cell. Vitamins & Hormones, Volume 95 . UK: Academic Press , pp. 249-267. ISBN 9780128001745
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Abstract
In addition its central role controlling systemic calcium homeostasis, the extracellular calcium-sensing receptor (CaSR) can be found on multiple cell-types not associated with controlling plasma calcium. The endocrine pancreas is one such tissue and it is apparent that the receptor plays an important role in regulating β-cell function. During exocytosis, divalent cations are co-released with insulin and their concentration within the restricted intercellular compartments of the pancreatic islet increases sufficiently to activate the CaSR on neighboring cells. Acute and chronic activation of the receptor has multiple effects on the β-cell, from increasing cadherin-based cell-cell adhesion, to directly altering the expression and function of various potassium and voltage-dependent calcium channels. The promiscuous activation of multiple binding partners improves cell-adhesion, cell-coupling and cell-to-cell communication within the islet and is the basis for the effect of the CaSR on β-cell function and improved glucose-responsiveness.
Item Type: | Book Item | ||||
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Subjects: | Q Science > QP Physiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Series Name: | Vitamins & Hormones | ||||
Publisher: | Academic Press | ||||
Place of Publication: | UK | ||||
ISBN: | 9780128001745 | ||||
Book Title: | The Pancreatic beta-cell | ||||
Editor: | Litwack, Gerald | ||||
Official Date: | 24 February 2014 | ||||
Dates: |
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Volume: | Volume 95 | ||||
Number of Pages: | 482 | ||||
Page Range: | pp. 249-267 | ||||
DOI: | http://dx.doi.org/10.1016/B978-0-12-800174-5.00010-7 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Copyright Holders: | Academic Press | ||||
Description: | Review |
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Funder: | Diabetes UK | ||||
Grant number: | BDA:09/0003913 and BDA:12/0004546 |
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