Fielding, Andrew B. and Royle, Stephen J. (2013) Mitotic inhibition of clathrin-mediated endocytosis. Cellular and Molecular Life Sciences, Volume 70 (Number 18). pp. 3423-3433. doi:10.1007/s00018-012-1250-8 ISSN 1420-682X.
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Abstract
Endocytosis and mitosis are fundamental processes in a cell’s life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Journal or Publication Title: | Cellular and Molecular Life Sciences |
| Publisher: | Springer |
| ISSN: | 1420-682X |
| Official Date: | September 2013 |
| Dates: | Date Event September 2013 Published |
| Volume: | Volume 70 |
| Number: | Number 18 |
| Page Range: | pp. 3423-3433 |
| DOI: | 10.1007/s00018-012-1250-8 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| URI: | https://wrap.warwick.ac.uk/59675/ |
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