Fielding, Andrew B. and Royle, Stephen J. (2013) Mitotic inhibition of clathrin-mediated endocytosis. Cellular and Molecular Life Sciences, Volume 70 (Number 18). pp. 3423-3433. doi:10.1007/s00018-012-1250-8

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Abstract

Endocytosis and mitosis are fundamental processes in a cell’s life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Cellular and Molecular Life Sciences
Publisher:	Springer
ISSN:	1420-682X
Official Date:	September 2013
Dates:	Date Event September 2013 Published
Volume:	Volume 70
Number:	Number 18
Page Range:	pp. 3423-3433
DOI:	10.1007/s00018-012-1250-8
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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