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Association of CHMP4B and autophagy with micronuclei : implications for cataract formation
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Sagona, Antonia P., Nezis, Ioannis P. and Stenmark, H. (Harald) (2014) Association of CHMP4B and autophagy with micronuclei : implications for cataract formation. BioMed Research International, Volume 2014 . Article number 974393. doi:10.1155/2014/974393 ISSN 2314-6133.
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Official URL: http://dx.doi.org/10.1155/2014/974393
Abstract
Autophagy is a mechanism of cellular self-degradation that is very important for cellular homeostasis and differentiation. Components of the endosomal sorting complex required for transport (ESCRT) machinery are required for endosomal sorting and also for autophagy and the completion of cytokinesis. Here we show that the ESCRT-III subunit CHMP4B not only localizes to normal cytokinetic bridges but also to chromosome bridges and micronuclei, the latter surrounded by lysosomes and autophagosomes. Moreover, CHMP4B can be co-immunoprecipitated with chromatin. Interestingly, a CHMP4B mutation associated with autosomal dominant posterior polar cataract abolishes the ability of CHMP4B to localize to micronuclei. We propose that CHMP4B, through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin. This may have implications for DNA degradation during lens cell differentiation, thus potentially protecting lens cells from cataract development.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Cataract -- Genetic aspects, Autophagic vacuoles, Cytokinesis | ||||
| Journal or Publication Title: | BioMed Research International | ||||
| Publisher: | Hindawi Publishing Corporation | ||||
| ISSN: | 2314-6133 | ||||
| Official Date: | 2014 | ||||
| Dates: |
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| Volume: | Volume 2014 | ||||
| Number of Pages: | 10 | ||||
| Article Number: | Article number 974393 | ||||
| DOI: | 10.1155/2014/974393 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Date of first compliant deposit: | 26 December 2015 | ||||
| Date of first compliant Open Access: | 26 December 2015 | ||||
| Funder: | European Research Council (ERC), Universitetet i Oslo. Medisinske Fakultet. Senter for kreftbiomedisin [Centre for Cancer Biomedicine], National Programme for Research in Functional Genomics in Norway (FUGE), Norges forskningsråd [Norwegian Research Council] | ||||
| Grant number: | 179571 (NRC) |
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