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The proliferating cell hypothesis : a metabolic framework for Plasmodium growth and development

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Salcedo-Sora, J. Enrique, Caamano-Gutierrez, Eva, Ward, Stephen A. and Biagini, Giancarlo A. (2014) The proliferating cell hypothesis : a metabolic framework for Plasmodium growth and development. Trends in Parasitology, Volume 30 (Number 4). pp. 170-175. doi:10.1016/j.pt.2014.02.001 ISSN 1471-4922.

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Official URL: http://dx.doi.org/10.1016/j.pt.2014.02.001

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Abstract

We hypothesise that intraerythrocytic malaria parasite metabolism is not merely fulfilling the need for ATP generation, but is evolved to support rapid proliferation, similar to that seen in other rapidly proliferating cells such as cancer cells. Deregulated glycolytic activity coupled with impaired mitochondrial metabolism is a metabolic strategy to generate glycolytic intermediates essential for rapid biomass generation for schizogony. Further, we discuss the possibility that Plasmodium metabolism is not only a functional consequence of the ‘hard-wired’ genome and argue that metabolism may also have a causal role in triggering the cascade of events that leads to developmental stage transitions. This hypothesis offers a framework to rationalise the observations of aerobic glycolysis, atypical mitochondrial metabolism, and metabolic switching in nonproliferating stages.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Divisions: Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Library of Congress Subject Headings (LCSH): Cell proliferation, Plasmodia
Journal or Publication Title: Trends in Parasitology
Publisher: Elsevier Science BV
ISSN: 1471-4922
Official Date: April 2014
Dates:
DateEvent
April 2014Published
Volume: Volume 30
Number: Number 4
Page Range: pp. 170-175
DOI: 10.1016/j.pt.2014.02.001
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 26 December 2015
Date of first compliant Open Access: 26 December 2015
Funder: Medical Research Council (Great Britain) (MRC), Wellcome Trust (London, England), University of Warwick, Liverpool School of Tropical Medicine

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