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The proliferating cell hypothesis : a metabolic framework for Plasmodium growth and development
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Salcedo-Sora, J. Enrique, Caamano-Gutierrez, Eva, Ward, Stephen A. and Biagini, Giancarlo A. (2014) The proliferating cell hypothesis : a metabolic framework for Plasmodium growth and development. Trends in Parasitology, Volume 30 (Number 4). pp. 170-175. doi:10.1016/j.pt.2014.02.001 ISSN 1471-4922.
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Official URL: http://dx.doi.org/10.1016/j.pt.2014.02.001
Abstract
We hypothesise that intraerythrocytic malaria parasite metabolism is not merely fulfilling the need for ATP generation, but is evolved to support rapid proliferation, similar to that seen in other rapidly proliferating cells such as cancer cells. Deregulated glycolytic activity coupled with impaired mitochondrial metabolism is a metabolic strategy to generate glycolytic intermediates essential for rapid biomass generation for schizogony. Further, we discuss the possibility that Plasmodium metabolism is not only a functional consequence of the ‘hard-wired’ genome and argue that metabolism may also have a causal role in triggering the cascade of events that leads to developmental stage transitions. This hypothesis offers a framework to rationalise the observations of aerobic glycolysis, atypical mitochondrial metabolism, and metabolic switching in nonproliferating stages.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre | ||||
| Library of Congress Subject Headings (LCSH): | Cell proliferation, Plasmodia | ||||
| Journal or Publication Title: | Trends in Parasitology | ||||
| Publisher: | Elsevier Science BV | ||||
| ISSN: | 1471-4922 | ||||
| Official Date: | April 2014 | ||||
| Dates: |
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| Volume: | Volume 30 | ||||
| Number: | Number 4 | ||||
| Page Range: | pp. 170-175 | ||||
| DOI: | 10.1016/j.pt.2014.02.001 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Date of first compliant deposit: | 26 December 2015 | ||||
| Date of first compliant Open Access: | 26 December 2015 | ||||
| Funder: | Medical Research Council (Great Britain) (MRC), Wellcome Trust (London, England), University of Warwick, Liverpool School of Tropical Medicine |
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