Piya, Milan K., Harte, A. L., Sivakumar, Kavitha, Tripathi, Gyanendra, Voyias, Philip D., James, S., Sabico, Shaun, Al-Daghri, Nasser M., Saravanan, Ponnusamy, Barber, T. M., Kumar, Sudhesh, Vatish, Manu and McTernan, P. G. (2014) The identification of irisin in human cerebrospinal fluid : influence of adiposity, metabolic markers, and gestational diabetes. AJP : Endocrinology and Metabolism , 306 (5). E512-E518. doi:10.1152/ajpendo.00308.2013 ISSN 0193-1849.

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Abstract

Peripheral action of irisin improves glucose homeostasis and increases energy expenditure, with no data on a central role of irisin in metabolism. These studies sought to examine 1) presence of irisin in human cerebrospinal fluid (CSF) and banked human hypothalamic tissue, 2) serum irisin in maternal subjects across varying adiposities with or without gestational diabetes (GDM), and 3) their respective neonate offspring. CSF, serum, and neonatal cord serum were collected from 91 pregnant women with and without GDM attending for an elective cesarean section [body mass index (BMI): 37.7 ± 7.6 kg/m2; age: 32 ± 8.3 yr]. Irisin was assessed by ELISA and correlated with biochemical and anthropometric data. Irisin expression was examined in human hypothalamus by immunohistochemical staining. Serum irisin in pregnant women was significantly lower in nonobese compared with obese and GDM subjects, after adjusting for BMI, lipids, and glucose. Irisin was present in neonatal cord serum (237 ± 8 ng/ml) and maternal CSF (32 ± 1.5 ng/ml). CSF irisin correlated positively with serum irisin levels from nonobese and obese pregnant women (P < 0.01), with CSF irisin significantly raised in GDM subjects (P < 0.05). Irisin was present in human hypothalamic sections in the paraventricular neurons, colocalized with neuropeptide Y. Irisin was detectable in CSF and in paraventricular neurons. Maternal serum irisin was lower in nonobese pregnant women after adjusting for BMI and a number of metabolic parameters. These studies indicate that irisin may have a central role in metabolism in addition to the known peripheral role. Further studies investigating the central action of irisin in human metabolic disease are required.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	AJP : Endocrinology and Metabolism
Publisher:	American Physiological Society
ISSN:	0193-1849
Official Date:	2014
Dates:	Date Event 2014 Published
Volume:	306
Number:	5
Page Range:	E512-E518
DOI:	10.1152/ajpendo.00308.2013
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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