The Library
Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens : a one-year prospective study
Tools
Alkharfy, Khalid M., Al-Daghri, Nasser M., Sabico, Shaun, Al-Othman, Abdulaziz, Moharram, Osama, Alokail, Majed S., Al-Saleh, Yousef, Kumar, Sudhesh and Chrousos, George P. (2013) Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens : a one-year prospective study. Cardiovascular Diabetology, Volume 12 (Number 1). Article number 113. doi:10.1186/1475-2840-12-113 ISSN 1475-2840.
|
PDF
WRAP_1475-2840-12-113.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 2.0.. Download (646Kb) | Preview |
Official URL: http://dx.doi.org/10.1186/1475-2840-12-113
Abstract
Background
Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objective of this study was to determine the effect of vitamin D3 supplementation in a cohort of Saudi DMT2 population on diet, insulin and/or different oral hypoglycemic agents and compare them with a non-DMT2 control cohort.
Methods
A total of 499 randomly selected Saudi subjects divided into 8 groups [Non-DMT2 Control = 151; Rosiglitazone alone = 49; Diet = 15; Insulin alone = 55; Insulin + Orals = 12; Metformin alone = 121; Oral agents combination = 37; Sulphonylurea alone = 59] were included in this 12-month interventional study. All DMT2 patients were given 2000 IU vitamin D3 daily, while the control group received none but were advised to increase sun exposure. Anthropometrics, glucose, lipid profile and 25-hydroxyvitamin D (25-OHVitD) were measured at baseline, 6 and 12 months.
Results
Circulating 25-OHVitD concentrations improved in all patient groups. The metformin group showed the highest change in circulating vitamin D levels both at 6 months (62.6%) and 12 months (50.6%) as compared to baseline (p < 0.001). No significant changes were observed in the BMI and glucose in any of the DMT2 groups. In contrast, the insulin + oral agents group showed more significant improvements in the metabolic profile, which included triglycerides and total cholesterol, as well as systolic blood pressure and HDL-cholesterol in males. Also, significant decreases in triglycerides were observed in the rosiglitazone and insulin + oral hypoglycemic agent groups both at 6 and 12 months of supplementation (both p-values <0.001).
Conclusion
While in all DMT2 groups circulating levels of 25-OHVitD increased after supplementation, in DMT2 patients on insulin in combination with other drugs benefitted the most in improving cardiovascular risk. Metformin improves 25-hydroxyvitamin D levels but did not seem to confer other added cardiometabolic benefits.
Keywords: Vitamin D; Vitamin D supplementation; Diabetes mellitus; Anti-diabetes therapies
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Non-insulin-dependent diabetes -- Treatment, Cholecalciferol -- Therapeutic use, Vitamin D -- Therapeutic use | ||||
Journal or Publication Title: | Cardiovascular Diabetology | ||||
Publisher: | Biomed Central | ||||
ISSN: | 1475-2840 | ||||
Official Date: | 2013 | ||||
Dates: |
|
||||
Volume: | Volume 12 | ||||
Number: | Number 1 | ||||
Article Number: | Article number 113 | ||||
DOI: | 10.1186/1475-2840-12-113 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 26 December 2015 | ||||
Date of first compliant Open Access: | 26 December 2015 | ||||
Funder: | Madīnat al-Malik ʻAbd al-ʻAzīz lil-ʻUlūm wa-al-Tiqnīyah [King Abdulaziz City for Science and Technology] (KACST) | ||||
Grant number: | AT-29-38 (KACST) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year