Sleep duration and all-cause mortality : a systematic review and meta-analysis of prospective studies
Cappuccio, Francesco P., D'Elia, Lanfranco, Strazzullo, Pasquale and Miller, Michelle A., Dr.. (2010) Sleep duration and all-cause mortality : a systematic review and meta-analysis of prospective studies. Sleep, Vol.33 (No.5). pp. 585-592. ISSN 0161-8105Full text not available from this repository.
Official URL: http://www.journalsleep.org/viewabstract.aspx?pid=...
Background: Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes.
Objectives: To assess whether the population longitudinal evidence supports the presence of a relationship between duration of sleep and all-cause mortality, to investigate both short and long sleep duration and to obtain an estimate of the risk.
Methods: We performed a systematic search of publications using MEDLINE (1966-2009), EMBASE (from 1980), the Cochrane Library, and manual searches without language restrictions. We included studies if they were prospective, had follow-up >3 years, had duration of sleep at baseline, and all-cause mortality prospectively. We extracted relative risks (RR) and 95% confidence intervals (CI) and pooled them using a random effect model. We carried out sensitivity analyses and assessed heterogeneity and publication bias.
Results: Overall, the 16 studies analyzed provided 27 independent cohort samples. They included 1,382,999 male and female participants (follow-up range 4 to 25 years), and 112,566 deaths. Sleep duration was assessed by questionnaire and outcome through death certification. In the pooled analysis, short duration of sleep was associated with a greater risk of death (RR: 1.12; 95% CI 1.06 to 1.18; P <0.01) with no evidence of publication bias (P = 0.74) but heterogeneity between studies (P = 0.02). Long duration of sleep was also associated with a greater risk of death (1.30; [1.22 to 1.38]; P < 0.0001) with no evidence of publication bias (P = 0.18) but significant heterogeneity between studies (P < 0.0001).
Conclusion: Both short and long duration of sleep are significant predictors of death in prospective population studies.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Sleep, Systematic reviews (Medical research), Meta-analysis, Mortality|
|Journal or Publication Title:||Sleep|
|Publisher:||American Academy of Sleep Medicine|
|Official Date:||1 May 2010|
|Number of Pages:||8|
|Page Range:||pp. 585-592|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Seventh Framework Programme (European Commission) (FP7)|
|Grant number:||FP7-HEALTH-2007-201550 (FP7)|
1. Akerstedt T, Nilsson PM. Sleep as restitution: an introduction. J Intern
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