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Sleep duration and all-cause mortality : a systematic review and meta-analysis of prospective studies

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Cappuccio, Francesco, D'Elia, Lanfranco, Strazzullo, Pasquale and Miller, Michelle A., Dr.. (2010) Sleep duration and all-cause mortality : a systematic review and meta-analysis of prospective studies. Sleep, Vol.33 (No.5). pp. 585-592. ISSN 0161-8105

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Official URL: http://www.journalsleep.org/viewabstract.aspx?pid=...

Abstract

Background: Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes. Objectives: To assess whether the population longitudinal evidence supports the presence of a relationship between duration of sleep and all-cause mortality, to investigate both short and long sleep duration and to obtain an estimate of the risk. Methods: We performed a systematic search of publications using MEDLINE (1966-2009), EMBASE (from 1980), the Cochrane Library, and manual searches without language restrictions. We included studies if they were prospective, had follow-up >3 years, had duration of sleep at baseline, and all-cause mortality prospectively. We extracted relative risks (RR) and 95% confidence intervals (CI) and pooled them using a random effect model. We carried out sensitivity analyses and assessed heterogeneity and publication bias. Results: Overall, the 16 studies analyzed provided 27 independent cohort samples. They included 1,382,999 male and female participants (follow-up range 4 to 25 years), and 112,566 deaths. Sleep duration was assessed by questionnaire and outcome through death certification. In the pooled analysis, short duration of sleep was associated with a greater risk of death (RR: 1.12; 95% CI 1.06 to 1.18; P <0.01) with no evidence of publication bias (P = 0.74) but heterogeneity between studies (P = 0.02). Long duration of sleep was also associated with a greater risk of death (1.30; [1.22 to 1.38]; P < 0.0001) with no evidence of publication bias (P = 0.18) but significant heterogeneity between studies (P < 0.0001). Conclusion: Both short and long duration of sleep are significant predictors of death in prospective population studies.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Sleep, Systematic reviews (Medical research), Meta-analysis, Mortality
Journal or Publication Title: Sleep
Publisher: American Academy of Sleep Medicine
ISSN: 0161-8105
Date: 1 May 2010
Volume: Vol.33
Number: No.5
Number of Pages: 8
Page Range: pp. 585-592
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Seventh Framework Programme (European Commission) (FP7)
Grant number: FP7-HEALTH-2007-201550 (FP7)
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URI: http://wrap.warwick.ac.uk/id/eprint/5980

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