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Expression of calcitonin gene-related peptide, adrenomedullin, and receptor modifying proteins in human adipose tissue and alteration in their expression with menopause status
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Gupta, Pratima, Harte, Alison L., da Silva, Nancy F., Khan, Hassan, Barnett, Anthony H., Kumar, Sudhesh , Sturdee, David W. and McTernan, P. G. (Philip G.) (2007) Expression of calcitonin gene-related peptide, adrenomedullin, and receptor modifying proteins in human adipose tissue and alteration in their expression with menopause status. Menopause, Volume 14 (Number 6). pp. 1031-1038. doi:10.1097/gme.0b013e31803c56b6 ISSN 1072-3714.
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Official URL: http://dx.doi.org/10.1097/gme.0b013e31803c56b6
Abstract
Calcitonin gene-related peptide (CGRP) is a vasoactive, proinflammatory neuropeptide implicated in the pathogenesis of cardiovascular disease. Elevated CGRP levels during hot flushes and pregnancy suggest that reproductive hormones may influence CGRP secretion. CGRP and the related protein adrenomedullin (ADM) may function through adipose tissue-mediated effects, since adipose tissue is an important site of cytokine production and the main site for estrogen production after menopause. This study examined mRNA and protein expression of CGRP, ADM, and the receptor activity-modifying proteins and the effects of menopausal status in human adipose tissue.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Menopause | ||||
Publisher: | Lippincott Williams & Wilkins | ||||
ISSN: | 1072-3714 | ||||
Official Date: | 2007 | ||||
Dates: |
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Volume: | Volume 14 | ||||
Number: | Number 6 | ||||
Page Range: | pp. 1031-1038 | ||||
DOI: | 10.1097/gme.0b013e31803c56b6 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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