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Resistin, central obesity, and type 2 diabetes
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McTernan, Claire L., McTernan, P. G. (Philip G.), Harte, A. L. (Alison L.), Levick, P. L., Barnett, A. H. and Kumar, Sudhesh (2002) Resistin, central obesity, and type 2 diabetes. The Lancet, Volume 359 (Number 9300). pp. 46-47. doi:10.1016/S0140-6736(02)07281-1
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Official URL: http://dx.doi.org/10.1016/S0140-6736(02)07281-1
Abstract
Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | The Lancet | ||||
| Publisher: | Lancet Publishing Group | ||||
| ISSN: | 0140-6736 | ||||
| Official Date: | 2002 | ||||
| Dates: |
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| Volume: | Volume 359 | ||||
| Number: | Number 9300 | ||||
| Page Range: | pp. 46-47 | ||||
| DOI: | 10.1016/S0140-6736(02)07281-1 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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