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Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome
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Tan, Bee K., Chen, Jing, Hu, Jiamiao, Amar, Omar, Mattu, Harman, Adya, Raghu, Patel, Vanlata H., Ramanjaneya, Manjunath, Lehnert, Hendrik and Randeva, Harpal S. (2013) Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 98 (12). E1891-E1900. doi:10.1210/jc.2013-2227
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Official URL: http://dx.doi.org/10.1210/jc.2013-2227
Abstract
Recently cartonectin was reported as a novel adipokine, with lower levels in diet-induced obese mice, glucose-lowering effects, and antiinflammatory and cardioprotective properties. Polycystic ovary syndrome (PCOS) is a proinflammatory state associated with obesity, diabetes, dyslipidemia, and cardiovascular complications.
Objectives:
The objective of the study was to investigate cartonectin levels and regulation in sera and adipose tissue (AT) as well as the effects of metformin of women with PCOS and control subjects.
Design:
This was a cross-sectional study [PCOS (n = 83) and control (n = 39) subjects]. Real-time PCR and Western blotting were used to assess mRNA and protein expression of cartonectin. Serum cartonectin was measured by an ELISA.
Results:
Serum and omental adipose tissue cartonectin were significantly lower in women with PCOS compared with control subjects (P < .05 and P < .01, respectively). Furthermore, cartonectin showed a significant negative association with body mass index, waist to hip ratio, glucose, insulin, total cholesterol, low-density lipoprotein-cholesterol, triglycerides, High sensitivity C-reactive protein (hs-CRP) and intima-media thickness (P < .05 and P < .01, respectively); in multiple regression analyses, triglycerides (P =.040) and hs-CRP (P = .031) were predictive of cartonectin levels (P < .05). After 6 months of metformin treatment, there was an associated increase in serum cartonectin (P < .05). Importantly, changes in hs-CRP were significantly negatively correlated with changes in serum cartonectin (P = .033). Finally, cartonectin protein production and secretion into conditioned media were significantly increased by metformin in control human omental AT explants (P < .05).
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | The Journal of Clinical Endocrinology & Metabolism | ||||||||||
| Publisher: | The Endocrine Society | ||||||||||
| ISSN: | 0021-972X | ||||||||||
| Official Date: | December 2013 | ||||||||||
| Dates: |
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| Volume: | 98 | ||||||||||
| Number: | 12 | ||||||||||
| Page Range: | E1891-E1900 | ||||||||||
| DOI: | 10.1210/jc.2013-2227 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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