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Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients
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Keir, R., Evans, Neil D., Hutchison, C. A., Vigano, M. R., Stella, A., Fabbrini, P., Storr, M. and Chappell, M. J. (Michael J.) (2012) Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 284-289. ISBN 9783902823106. doi:10.3182/20120829-3-HU-2029.00057 ISSN 1474-6670.
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Official URL: http://dx.doi.org/10.3182/20120829-3-HU-2029.00057
Abstract
A two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. Before using clinical data to estimate the model's unknown parameters, structural identifiability analysis was performed to determine the parameters uniqueness given certain clinical observations. A Taylor series expansion method was implemented which found that the model was structurally globally/uniquely identifiable for both on- and off-dialysis phases. The fitted model was then used in a predictive capacity showing that the use of Theralite High Cut-off (HCO) or HCO 1100 dialyser gave a significant reduction in myoglobin renal exposure compared to standard haemodialysis (HD)
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Journal or Publication Title: | Biological and Medical Systems | ||||
| Publisher: | International Federation of Automatic Control | ||||
| ISBN: | 9783902823106 | ||||
| ISSN: | 1474-6670 | ||||
| Book Title: | 8th IFAC Symposium on Biological and Medical Systems (2012) | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Volume 8 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 284-289 | ||||
| DOI: | 10.3182/20120829-3-HU-2029.00057 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 8th IFAC Symposium on Biological and Medical Systems | ||||
| Type of Event: | Other | ||||
| Location of Event: | Budapest, Hungary | ||||
| Date(s) of Event: | 29-31 Aug 2012 | ||||
| Related URLs: |
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