Cross, R. A. and McAinsh, Andrew D. (2014) Prime movers : mechanochemistry of mitotic kinesins. Nature Reviews Molecular Cell Biology, Volume 15 . pp. 257-271. doi:10.1038/nrm3768 ISSN 1471-0072.

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Abstract

Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams. Different kinesins walk directionally along dynamic microtubules, anchor, crosslink, align and sort microtubules into polarized bundles, and influence microtubule dynamics by interacting with microtubule tips. The mechanochemical mechanisms of these kinesins are specialized to enable each type to make a specific contribution to spindle self-organization and chromosome segregation.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Kinesin, Spindle (Cell division), Cell division
Journal or Publication Title:	Nature Reviews Molecular Cell Biology
Publisher:	Nature Publishing Group
ISSN:	1471-0072
Official Date:	21 March 2014
Dates:	Date Event 21 March 2014 Published
Volume:	Volume 15
Page Range:	pp. 257-271
DOI:	10.1038/nrm3768
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Date of first compliant deposit:	26 December 2015
Date of first compliant Open Access:	26 December 2015

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