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Modelling of tumour growth and cytotoxic effect of taxotere in xenografts
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Evans, Neil D., Dimelow, Richard and Yates, James (2012) Modelling of tumour growth and cytotoxic effect of taxotere in xenografts. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems pp. 278-283. doi:10.3182/20120829-3-HU-2029.00051 ISSN 1474-6670.
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Official URL: http://dx.doi.org/10.3182/20120829-3-HU-2029.00051
Abstract
One of the major sources of information on physiological and pathophysiological effects in pre-clinical oncology studies is the xenografted tumour animal model. However, measurement of tumour volume over time potentially masks a range of biological changes that the xenograft is undergoing. In this paper a mechanistic model of tumour growth in xenografts is presented that can be used to investigate the mode of drug action with respect to phenotypic changes. The model encapsulates key histological biomarkers and spatial constraints. The unknown model parameters are first shown to be uniquely identifiable from the proposed experimental studies, and then estimated from the resulting data using the anti-cancer agent taxotere.
Item Type: | Conference Item (Paper) | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Journal or Publication Title: | Biological and Medical Systems | ||||
Publisher: | IFAC Secretariat | ||||
ISSN: | 1474-6670 | ||||
Book Title: | 8th IFAC Symposium on Biological and Medical Systems (2012) | ||||
Official Date: | 2012 | ||||
Dates: |
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Page Range: | pp. 278-283 | ||||
DOI: | 10.3182/20120829-3-HU-2029.00051 | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | 8th IFAC Symposium on Biological and Medical Systems | ||||
Type of Event: | Other | ||||
Location of Event: | Budapest, Hungary | ||||
Date(s) of Event: | 29-31 Aug 2012 | ||||
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