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Structural identifiability and indistinguishability analyses of in vitro pitavastatin hepatic uptake
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Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, J. T. W. and Evans, Neil D. (2012) Structural identifiability and indistinguishability analyses of in vitro pitavastatin hepatic uptake. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 361-366. doi:10.3182/20120829-3-HU-2029.00087 ISSN 1474-6670.
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Official URL: http://dx.doi.org/10.3182/20120829-3-HU-2029.00087
Abstract
In this paper a review of the application of four different techniques (a version of the similarity transformation approach for autonomous uncontrolled systems, a non-differential input/output observable normal form approach, the characteristic set differential algebra and a recent algebraic input/output relationship approach) to determine the structural identifiability and indistinguishability of certain in vitro nonlinear pharmacokinetic models is provided. The Organic Anion Transporting Polypeptide (OATP) substrate, Pitavastatin, is used as a probe on freshly isolated animal and human hepatocytes. Candidate pharmacokinetic non-linear compartmental models have been derived to characterise the uptake process of Pitavastatin. As a prerequisite to parameter estimation, structural identifiability analyses are performed to establish that all unknown parameters can be identified from the experimental observations available. Furthermore, a structural indistinguishability analysis was performed to establish that all candidate models were structurally distinguishable for the given observations. This work is supported by the UK MRC Capacity Building Initiative and AstraZeneca.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Journal or Publication Title: | Biological and Medical Systems | ||||
| Publisher: | IFAC Secretariat | ||||
| ISSN: | 1474-6670 | ||||
| Book Title: | 8th IFAC Symposium on Biological and Medical Systems (2012) | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Volume 8 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 361-366 | ||||
| DOI: | 10.3182/20120829-3-HU-2029.00087 | ||||
| Status: | Not Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 8th IFAC Symposium on Biological and Medical Systems | ||||
| Type of Event: | Other | ||||
| Location of Event: | Budapest, Hungary | ||||
| Date(s) of Event: | 29-31 Aug 2012 | ||||
| Related URLs: |
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