Lam, Eric W.-F., Brosens, Jan J., Gomes, Ana R. and Koo, Chuay-Yeng (2013) Forkhead box proteins : tuning forks for transcriptional harmony. Nature Reviews Cancer, Volume 13 (Number 7). pp. 482-495. doi:10.1038/nrc3539 ISSN 1474-175X.

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Abstract

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Nature Reviews Cancer
Publisher:	Nature Publishing Group
ISSN:	1474-175X
Official Date:	July 2013
Dates:	Date Event July 2013 Published
Volume:	Volume 13
Number:	Number 7
Page Range:	pp. 482-495
DOI:	10.1038/nrc3539
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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