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Forkhead box proteins : tuning forks for transcriptional harmony
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Lam, Eric W.-F., Brosens, Jan J., Gomes, Ana R. and Koo, Chuay-Yeng (2013) Forkhead box proteins : tuning forks for transcriptional harmony. Nature Reviews Cancer, Volume 13 (Number 7). pp. 482-495. doi:10.1038/nrc3539 ISSN 1474-175X.
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Official URL: http://dx.doi.org/10.1038/nrc3539
Abstract
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Nature Reviews Cancer | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1474-175X | ||||
Official Date: | July 2013 | ||||
Dates: |
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Volume: | Volume 13 | ||||
Number: | Number 7 | ||||
Page Range: | pp. 482-495 | ||||
DOI: | 10.1038/nrc3539 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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