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Unravelling the enigma of Perthes disease
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Perry, D. C. (2013) Unravelling the enigma of Perthes disease. Annals of The Royal College of Surgeons of England, Volume 95 (Number 5). pp. 311-316. doi:10.1308/003588413X13629960046192 ISSN 0035-8843.
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Official URL: http://dx.doi.org/10.1308/003588413X13629960046192
Abstract
Perthes disease is an idiopathic avascular necrosis of a juvenile hip. Although 2010 marked a century since it was first described, the aetiology remains unknown. It is suggested that adverse socioeconomic circumstances may be a key precipitant. This work describes recent studies that explore the disease epidemiology. Descriptive studies include a case register from Merseyside, hospital discharge data from Scotland, analysis of the world's largest community disease register (General Practice Research Database [GPRD]) and a systematic review of incidence. Analytical studies include a nested case-controlled study in the GPRD and a hospital case-controlled study. The studies demonstrated a striking north-south divide in the UK incidence of Perthes disease, similar to that seen in many adult diseases. There was a sustained fall in disease frequency in all studies, with a narrowing of the north-south divide. There was a strong association with area deprivation, independent of living in an urban environment. Internationally, equatorial regions were unaffected by disease and northern Europe had the highest incidence, which was primarily a function of race although latitude was an independent predictor. Individual characteristics associated with the disease were congenital anomalies of the genitourinary tract and a structural abnormality of arterial calibre. Despite a falling incidence, Perthes disease remains an important cause of child morbidity and exemplifies socioeconomic inequalities. A deprivation-related exposure, acting early in development, appears critical. The aetiological factor in Perthes disease remains elusive but it is likely that unravelling this enigma may unlock additional secrets pertaining to the developmental origins of this and other diseases.
| Item Type: | Journal Article | ||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Annals of The Royal College of Surgeons of England | ||||||
| Publisher: | The Royal College of Surgeons of England | ||||||
| ISSN: | 0035-8843 | ||||||
| Official Date: | July 2013 | ||||||
| Dates: |
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| Volume: | Volume 95 | ||||||
| Number: | Number 5 | ||||||
| Page Range: | pp. 311-316 | ||||||
| DOI: | 10.1308/003588413X13629960046192 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Open Access Version: |
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