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Enzymology of the carotenoid cleavage dioxygenases : Reaction mechanisms, inhibition and biochemical roles
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Harrison, Peter J. and Bugg, Tim (2014) Enzymology of the carotenoid cleavage dioxygenases : Reaction mechanisms, inhibition and biochemical roles. Archives of Biochemistry and Biophysics, Volume 544 . pp. 105-111. doi:10.1016/j.abb.2013.10.005 ISSN 0003-9861.
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Official URL: http://dx.doi.org/10.1016/j.abb.2013.10.005
Abstract
Carotenoid cleavage dioxygenases (CCDs) are a large family of non-heme iron (II) dependent enzymes. CCDs catalyse the selective oxidative cleavage of carotenoids to produce apocarotenoids. Apocarotenoid derived molecules form important signalling molecules in plants in the form of abscisic acid and strigolactone and in mammals in the form of retinal. Very little is known biochemically about the CCDs and only a handful of CCDs have been biochemically characterised. Mechanistically, debate surrounds whether CCDs utilise a mono or dioxygenase mechanism. Here, we review the biochemical roles of CCDs, discuss the mechanisms by which CCD cleavage is proposed to occur, and discuss recent reports of selective CCD enzyme inhibitors.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
Journal or Publication Title: | Archives of Biochemistry and Biophysics | ||||||
Publisher: | Academic Press | ||||||
ISSN: | 0003-9861 | ||||||
Official Date: | 15 February 2014 | ||||||
Dates: |
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Volume: | Volume 544 | ||||||
Page Range: | pp. 105-111 | ||||||
DOI: | 10.1016/j.abb.2013.10.005 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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