Haworth, Claire M. A. and Davis, Oliver S. P. (2014) From observational to dynamic genetics. Frontiers in Genetics, Volume 5 . Article number 6. doi:10.3389/fgene.2014.00006 ISSN 1664-8021.

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Abstract

Twin and family studies have shown that most traits are at least moderately heritable. But what are the implications of finding genetic influence for the design of intervention and prevention programs? For complex traits, heritability does not mean immutability, and research has shown that genetic influences can change with age, context, and in response to behavioral and drug interventions. The most significant implications for intervention will come when we move from observational genetics to investigating dynamic genetics, including genetically sensitive interventions. Future interventions should be designed to overcome genetic risk and draw upon genetic strengths by changing the environment.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science, Engineering and Medicine > Science > Psychology
Library of Congress Subject Headings (LCSH):	Genetics, Genetic engineering
Journal or Publication Title:	Frontiers in Genetics
Publisher:	Frontiers Research Foundation
ISSN:	1664-8021
Official Date:	21 January 2014
Dates:	Date Event 21 January 2014 Published 7 January 2014 Accepted 30 October 2013 Submitted
Volume:	Volume 5
Article Number:	Article number 6
DOI:	10.3389/fgene.2014.00006
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Funder:	British Academy (BA), Wellcome Trust (London, England)
Grant number:	WT088984 (WT)

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