The Library
Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men
Tools
Tools
Tools
Cartwright, Rufus, Mangera, Altaf, Tikkinen, Kari A. O., Rajan, Prabhakar, Pesonen, Jori, Kirby, Anna C., Thiagamoorthy, Ganesh, Ambrose, Chris, Gonzalez-Maffe, Juan, Bennett, Phillip R., Palmer, Tom M., Walley, Andrew, Jarvelin, Marjo-Riitta, Khullar, Vik and Chapple, Christopher R. (2014) Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men. European Urology . doi:10.1016/j.eururo.2014.01.007 ISSN 0302-2838.
|
PDF
WRAP_1-s2.0-S0302283814000190-main.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (1406Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.eururo.2014.01.007
Abstract
Context
Although family studies have shown that male lower urinary tract symptoms (LUTS) are highly heritable, no systematic review exists of genetic polymorphisms tested for association with LUTS.
Objective
To systematically review and meta-analyze studies assessing candidate polymorphisms/genes tested for an association with LUTS, and to assess the strength, consistency, and potential for bias among pooled associations.
Evidence acquisition
A systematic search of the PubMed and HuGE databases as well as abstracts of major urologic meetings was performed through to January 2013. Case-control studies reporting genetic associations in men with LUTS were included. Reviewers independently and in duplicate screened titles, abstracts, and full texts to determine eligibility, abstracted data, and assessed the credibility of pooled associations according to the interim Venice criteria. Authors were contacted for clarifications if needed. Meta-analyses were performed for variants assessed in more than two studies.
Evidence synthesis
We identified 74 eligible studies containing data on 70 different genes. A total of 35 meta-analyses were performed with statistical significance in five (ACE, ELAC2, GSTM1, TERT, and VDR). The heterogeneity was high in three of these meta-analyses. The rs731236 variant of the vitamin D receptor had a protective effect for LUTS (odds ratio: 0.64; 95% confidence interval, 0.49–0.83) with moderate heterogeneity (I2 = 27.2%). No evidence for publication bias was identified. Limitations include wide-ranging phenotype definitions for LUTS and limited power in most meta-analyses to detect smaller effect sizes.
Conclusions
Few putative genetic risk variants have been reliably replicated across populations. We found consistent evidence of a reduced risk of LUTS associated with the common rs731236 variant of the vitamin D receptor gene in our meta-analyses.
Patient summary
Combining the results from all previous studies of genetic variants that may cause urinary symptoms in men, we found significant variants in five genes. Only one, a variant of the vitamin D receptor, was consistently protective across different populations.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||
| Library of Congress Subject Headings (LCSH): | Urination disorders -- Genetic aspects | ||||||
| Journal or Publication Title: | European Urology | ||||||
| Publisher: | Elsevier BV | ||||||
| ISSN: | 0302-2838 | ||||||
| Official Date: | 22 January 2014 | ||||||
| Dates: |
|
||||||
| DOI: | 10.1016/j.eururo.2014.01.007 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 26 December 2015 | ||||||
| Date of first compliant Open Access: | 26 December 2015 | ||||||
| Funder: | International Continence Society, Medical Research Council (Great Britain) (MRC), Suomen Kulttuurirahasto [Finnish Cultural Foundation], Suomen Lääketieteen Säätiö [Finnish Medical Foundation], Suomen Akatemia [Academy of Finland], National Institute for Health Research (Great Britain). Biomedical Research Centre |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
