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Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents
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(2015) Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Molecular Psychiatry, 20 . pp. 263-274. doi:10.1038/mp.2013.197 ISSN 1359-4184.
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Official URL: http://dx.doi.org/10.1038/mp.2013.197
Abstract
Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children and adolescents, the genes contributing to individual differences in these traits remain unknown. We conducted a large-scale association study in 1583 adolescents to identify genes affecting cortical thickness. Single-nucleotide polymorphisms (SNPs; n=54 837) within genes whose expression changed between stages of growth and differentiation of a human neural stem cell line were selected for association analyses with average cortical thickness. We identified a variant, rs7171755, associating with thinner cortex in the left hemisphere (P=1.12 × 10−7), particularly in the frontal and temporal lobes. Localized effects of this SNP on cortical thickness differently affected verbal and nonverbal intellectual abilities. The rs7171755 polymorphism acted in cis to affect expression in the human brain of the synaptic cell adhesion glycoprotein-encoding gene NPTN. We also found that cortical thickness and NPTN expression were on average higher in the right hemisphere, suggesting that asymmetric NPTN expression may render the left hemisphere more sensitive to the effects of NPTN mutations, accounting for the lateralized effect of rs7171755 found in our study. Altogether, our findings support a potential role for regional synaptic dysfunctions in forms of intellectual deficits.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QM Human anatomy | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
Library of Congress Subject Headings (LCSH): | Brain -- Growth, Neural stem cells, Intelligence levels | ||||||||
Journal or Publication Title: | Molecular Psychiatry | ||||||||
Publisher: | Nature Publishing Group | ||||||||
ISSN: | 1359-4184 | ||||||||
Official Date: | August 2015 | ||||||||
Dates: |
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Volume: | 20 | ||||||||
Page Range: | pp. 263-274 | ||||||||
DOI: | 10.1038/mp.2013.197 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 26 December 2015 | ||||||||
Date of first compliant Open Access: | 26 December 2015 | ||||||||
Funder: | Sixth Framework Programme (European Commission) (FP6), Germany. Bundesministerium für Bildung und Forschung (BMBF), Seventh Framework Programme (European Commission) (FP7), Medical Research Council (Great Britain) (MRC), Socialvetenskapliga forskningsrådet (Sweden) (SF), National Institute for Health Research (Great Britain) (NIHR) | ||||||||
Grant number: | LSHM-CT- 2007-037286 (FP6), 01EV0711 (BMBF) | ||||||||
Embodied As: | 1 |
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