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Progression in disability and regional grey matter atrophy in relapsing-remitting multiple sclerosis
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Hofstetter, L., Naegelin, Y., Filli, L., Kuster, P., Traud, S., Smieskova, R., Mueller-Lenke, N., Kappos, L., Gass, A., Sprenger, T., Penner, I. -K., Nichols, Thomas E., Vrenken, H., Barkhof, F., Polman, C., Radue, E. -W., Borgwardt, S. J. and Bendfeldt, K. (2014) Progression in disability and regional grey matter atrophy in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal, Volume 20 (Number 2). pp. 202-213. doi:10.1177/1352458513493034 ISSN 1352-4585.
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Official URL: http://dx.doi.org/10.1177/1352458513493034
Abstract
Background: In multiple sclerosis (MS) regional grey matter (GM) atrophy has been associated with disability progression.
Objective: The aim of this study was to compare regional GM volume changes in relapsing–remitting MS (RRMS) patients with progressive and stable disability, using voxel-based morphometry (VBM).
Methods: We acquired baseline and 1-year follow-up 3-dimensional (3D) T1-weighted magnetic resonance imaging (MRI) data of RRMS patients, using two 1.5-Tesla scanners. Patients were matched pair-wise with respect to age, gender, disease duration, medication, scanner and baseline Expanded Disability Status Scale (EDSS) into 13 pairs, with either progressive EDSS (≥ 1 point change y-1) or stable EDSS, as well as into 29 pairs with either progressive Multiple Sclerosis Functional Composite (MSFC) at ≥ 0.25% decrease in y-1 in any component, or stable MSFC. We analysed longitudinal regional differences in GM volumes in the progressive and stable EDSS and MSFC groups, respectively, using VBM.
Results: Significant GM volume reductions occurred in the right precuneus, in the progressive EDSS group. Differential between-group effects occurred in the right precuneus and in the postcentral gyrus. Further longitudinal GM volume reductions occurred in the right orbicular gyrus, in the progressive MSFC group, but no between-group differences were observed (non-stationary cluster-wise inference, all P corrected < 0.05).
Conclusion: These results suggested a direct association of disability progression and regional GM atrophy in RRMS.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | ||||||
| Journal or Publication Title: | Multiple Sclerosis Journal | ||||||
| Publisher: | Sage Publications Ltd. | ||||||
| ISSN: | 1352-4585 | ||||||
| Official Date: | February 2014 | ||||||
| Dates: |
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| Volume: | Volume 20 | ||||||
| Number: | Number 2 | ||||||
| Page Range: | pp. 202-213 | ||||||
| DOI: | 10.1177/1352458513493034 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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