The Library
Electrochemical nanoprobes for single-cell analysis
Tools
(2014) Electrochemical nanoprobes for single-cell analysis. ACS Nano, Volume 8 (Number 1). pp. 875-884. doi:10.1021/nn405612q ISSN 1936-0851.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1021/nn405612q
Abstract
The measurement of key molecules in individual cells with minimal disruption to the biological milieu is the next frontier in single-cell analyses. Nanoscale devices are ideal analytical tools because of their small size and their potential for high spatial and temporal resolution recordings. Here, we report the fabrication of disk-shaped carbon nanoelectrodes whose radius can be precisely tuned within the range 5–200 nm. The functionalization of the nanoelectrode with platinum allowed the monitoring of oxygen consumption outside and inside a brain slice. Furthermore, we show that nanoelectrodes of this type can be used to impale individual cells to perform electrochemical measurements within the cell with minimal disruption to cell function. These nanoelectrodes can be fabricated combined with scanning ion conductance microscopy probes, which should allow high resolution electrochemical mapping of species on or in living cells.
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Journal or Publication Title: | ACS Nano | ||||||||||
Publisher: | American Chemical Society | ||||||||||
ISSN: | 1936-0851 | ||||||||||
Official Date: | 28 January 2014 | ||||||||||
Dates: |
|
||||||||||
Volume: | Volume 8 | ||||||||||
Number: | Number 1 | ||||||||||
Page Range: | pp. 875-884 | ||||||||||
DOI: | 10.1021/nn405612q | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |