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Progesterone action in the myometrium and decidua in preterm birth
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Blanks, Andrew M. and Brosens, Jan J. (2012) Progesterone action in the myometrium and decidua in preterm birth. Facts, Views & Vision in ObGyn, Volume 4 (Number 3). pp. 188-194.
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Official URL: http://www.fvvo.be/archive/volume-4/number-3/revie...
Abstract
Progesterone is central to many reproductive processes and is critical in regulating the menstrual cycle and maintaining pregnancy. We discuss here similarities in the molecular mechanisms that regulate the process of decidualisation in endometrial stromal cells and uterine quiescence in myometrial smooth muscle cells. We discuss recent evidence that the decidua may be an important mediator of progesterone actions in the onset of labor in mammalian species lacking progesterone withdrawal. These observations have relevance to recent clinical observations of the effect of progesterone administration in the prevention of preterm labor. We suggest that further research is required to understand the role of progesterone in maintaining the decidua in late pregnancy and particular focus should be given to the mechanisms that increase prostaglandin production in the uterus at term.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Progesterone, Decidua, Myometrium, Premature labor | ||||
| Journal or Publication Title: | Facts, Views & Vision in ObGyn | ||||
| Publisher: | Universa Press | ||||
| ISSN: | 2032-0418 | ||||
| Official Date: | September 2012 | ||||
| Dates: |
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| Volume: | Volume 4 | ||||
| Number: | Number 3 | ||||
| Page Range: | pp. 188-194 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
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