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Progesterone action in the myometrium and decidua in preterm birth

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Blanks, Andrew M. and Brosens, Jan J. (2012) Progesterone action in the myometrium and decidua in preterm birth. Facts, Views & Vision in ObGyn, Volume 4 (Number 3). pp. 188-194. ISSN 2032-0418.

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Abstract

Progesterone is central to many reproductive processes and is critical in regulating the menstrual cycle and maintaining pregnancy. We discuss here similarities in the molecular mechanisms that regulate the process of decidualisation in endometrial stromal cells and uterine quiescence in myometrial smooth muscle cells. We discuss recent evidence that the decidua may be an important mediator of progesterone actions in the onset of labor in mammalian species lacking progesterone withdrawal. These observations have relevance to recent clinical observations of the effect of progesterone administration in the prevention of preterm labor. We suggest that further research is required to understand the role of progesterone in maintaining the decidua in late pregnancy and particular focus should be given to the mechanisms that increase prostaglandin production in the uterus at term.

Item Type: Journal Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Progesterone, Decidua, Myometrium, Premature labor
Journal or Publication Title: Facts, Views & Vision in ObGyn
Publisher: Universa Press
ISSN: 2032-0418
Official Date: September 2012
Dates:
DateEvent
September 2012Published
Volume: Volume 4
Number: Number 3
Page Range: pp. 188-194
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 28 July 2016
Date of first compliant Open Access: 28 July 2016

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