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Autophagy in Drosophila : from historical studies to current knowledge
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Mulakkal, Nitha Charles, Nagy, Péter, Takats, Szabolcs, Tusco, Radu, Juhász, Gábor and Nezis, I. P. (2014) Autophagy in Drosophila : from historical studies to current knowledge. BioMed Research International, 2014 . 273473. doi:10.1155/2014/273473
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Official URL: http://dx.doi.org/10.1155/2014/273473
Abstract
The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field, and made it possible to carry out functional studies in model organisms. Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s. This review aims to summarize past achievements and our current knowledge about the role and regulation of autophagy in Drosophila, with an outlook to yeast and mammals. The basic mechanisms of autophagy in fruit fly cells appear to be quite similar to other eukaryotes, and the role that this lysosomal self-degradation process plays in Drosophila models of various diseases already made it possible to recognize certain aspects of human pathologies. Future studies in this complete animal hold great promise for the better understanding of such processes, and may also help finding new research avenues for the treatment of disorders with misregulated autophagy.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QL Zoology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Autophagic vacuoles, Drosophila | ||||||||
| Journal or Publication Title: | BioMed Research International | ||||||||
| Publisher: | Hindawi Publishing Corporation | ||||||||
| ISSN: | 2314-6133 | ||||||||
| Official Date: | 18 April 2014 | ||||||||
| Dates: |
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| Volume: | 2014 | ||||||||
| Article Number: | 273473 | ||||||||
| DOI: | 10.1155/2014/273473 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
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