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Autophagy in Drosophila : from historical studies to current knowledge

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Mulakkal, Nitha Charles, Nagy, Péter, Takats, Szabolcs, Tusco, Radu, Juhász, Gábor and Nezis, I. P. (2014) Autophagy in Drosophila : from historical studies to current knowledge. BioMed Research International, 2014 . 273473. doi:10.1155/2014/273473

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Official URL: http://dx.doi.org/10.1155/2014/273473

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Abstract

The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field, and made it possible to carry out functional studies in model organisms. Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s. This review aims to summarize past achievements and our current knowledge about the role and regulation of autophagy in Drosophila, with an outlook to yeast and mammals. The basic mechanisms of autophagy in fruit fly cells appear to be quite similar to other eukaryotes, and the role that this lysosomal self-degradation process plays in Drosophila models of various diseases already made it possible to recognize certain aspects of human pathologies. Future studies in this complete animal hold great promise for the better understanding of such processes, and may also help finding new research avenues for the treatment of disorders with misregulated autophagy.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QL Zoology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Autophagic vacuoles, Drosophila
Journal or Publication Title: BioMed Research International
Publisher: Hindawi Publishing Corporation
ISSN: 2314-6133
Official Date: 18 April 2014
Dates:
DateEvent
18 April 2014Available
17 April 2014Accepted
23 January 2014Submitted
Volume: 2014
Article Number: 273473
DOI: 10.1155/2014/273473
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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