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A pseudomonas aeruginosa type VI secretion phospholipase D effector targets both prokaryotic and eukaryotic cells
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Jiang, Feng, Waterfield, Nicholas R., Yang, Jian, Yang, Guowei and Jin, Qi (2014) A pseudomonas aeruginosa type VI secretion phospholipase D effector targets both prokaryotic and eukaryotic cells. Cell Host & Microbe, Volume 15 (Number 5). pp. 600-610. doi:10.1016/j.chom.2014.04.010 ISSN 1931-3128.
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Official URL: http://dx.doi.org/10.1016/j.chom.2014.04.010
Abstract
Widely found in animal and plant-associated proteobacteria, type VI secretion systems (T6SSs) are potentially capable of facilitating diverse interactions with eukaryotes and/or other bacteria. Pseudomonas aeruginosa encodes three distinct T6SS haemolysin coregulated protein (Hcp) secretion islands (H1, H2, and H3-T6SS), each involved in different aspects of the bacterium’s interaction with other organisms. Here we describe the characterization of a P. aeruginosa H3-T6SS-dependent phospholipase D effector, PldB, and its three tightly linked cognate immunity proteins. PldB targets the periplasm of prokaryotic cells and exerts an antibacterial activity. Surprisingly, PldB also facilitates intracellular invasion of host eukaryotic cells by activation of the PI3K/Akt pathway, revealing it to be a trans-kingdom effector. Our findings imply a potentially widespread T6SS-mediated mechanism, which deploys a single phospholipase effector to influence both prokaryotic cells and eukaryotic hosts.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Cell Host & Microbe | ||||||||||
Publisher: | Cell Press | ||||||||||
ISSN: | 1931-3128 | ||||||||||
Official Date: | 14 May 2014 | ||||||||||
Dates: |
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Volume: | Volume 15 | ||||||||||
Number: | Number 5 | ||||||||||
Page Range: | pp. 600-610 | ||||||||||
DOI: | 10.1016/j.chom.2014.04.010 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
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