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Virulence and pathogenesis of HIV-1 infection : an evolutionary perspective
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Fraser, Christophe, Lythgoe, Katrina A., Leventhal, Gabriel, Shirreff, George, Hollingsworth, T. Déirdre, Alizon, Samuel and Bonhoeffer, Sebastien (2014) Virulence and pathogenesis of HIV-1 infection : an evolutionary perspective. Science, Volume 343 (Number 6177). Article number 1243727. doi:10.1126/science.1243727
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Official URL: http://dx.doi.org/10.1126/science.1243727
Abstract
Why some individuals develop AIDS rapidly whereas others remain healthy without treatment for many years remains a central question of HIV research. An evolutionary perspective reveals an apparent conflict between two levels of selection on the virus. On the one hand, there is rapid evolution of the virus in the host, and on the other, new observations indicate the existence of virus factors that affect the virulence of infection whose influence persists over years in infected individuals and across transmission events. Here, we review recent evidence that shows that viral genetic factors play a larger role in modulating disease severity than anticipated. We propose conceptual models that reconcile adaptive evolution at both levels of selection. Evolutionary analysis provides new insight into HIV pathogenesis.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software Q Science > QR Microbiology Q Science > QR Microbiology > QR355 Virology R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Journal or Publication Title: | Science | ||||
| Publisher: | American Association for the Advancement of Science | ||||
| ISSN: | 0036-8075 | ||||
| Official Date: | 21 March 2014 | ||||
| Dates: |
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| Volume: | Volume 343 | ||||
| Number: | Number 6177 | ||||
| Article Number: | Article number 1243727 | ||||
| DOI: | 10.1126/science.1243727 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | Wellcome Trust, Medical Research Council, European Research Council |
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