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The source of respiratory syncytial virus infection in infants : a household cohort study in rural Kenya
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Munywoki, Patrick Kiio, Koech, Dorothy C., Agoti, Charles N., Lewa, Clement, Cane, Patricia, Medley, Graham and Nokes, D. James (2014) The source of respiratory syncytial virus infection in infants : a household cohort study in rural Kenya. Journal of Infectious Diseases, Volume 209 (Number 11). pp. 1685-1692. doi:10.1093/infdis/jit828 ISSN 0022-1899.
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Official URL: http://dx.doi.org/10.1093/infdis/jit828
Abstract
Background. Respiratory syncytial virus (RSV) vaccine development for direct protection of young infants faces substantial obstacles. Assessing the potential of indirect protection using different strategies, such as targeting older children or mothers, requires knowledge of the source of infection to the infants.
Methods. We undertook a prospective study in rural Kenya. Households with a child born after the preceding RSV epidemic and ≥1 elder sibling were recruited. Nasopharyngeal swab samples were collected every 3–4 days irrespective of symptoms from all household members throughout the RSV season of 2009–2010 and tested for RSV using molecular techniques.
Results. From 451 participants in 44 households a total of 15 396 nasopharyngeal swab samples were samples were collected, representing 86% of planned sampling. RSV was detected in 37 households (84%) and 173 participants (38%) and 28 study infants (64%). The infants acquired infection from within (15 infants; 54%) or outside (9 infants; 32%) the household; in 4 households the source of infant infection was inconclusive. Older children were index case patients for 11 (73%) of the within-household infant infections, and 10 of these 11 children were attending school.
Conclusion. We demonstrate that school-going siblings frequently introduce RSV into households, leading to infection in infants.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QR Microbiology > QR355 Virology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
| Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus -- Transmission -- Kenya, Infants -- Diseases -- Kenya | ||||||||||
| Journal or Publication Title: | Journal of Infectious Diseases | ||||||||||
| Publisher: | Oxford University Press | ||||||||||
| ISSN: | 0022-1899 | ||||||||||
| Official Date: | 1 June 2014 | ||||||||||
| Dates: |
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| Volume: | Volume 209 | ||||||||||
| Number: | Number 11 | ||||||||||
| Page Range: | pp. 1685-1692 | ||||||||||
| DOI: | 10.1093/infdis/jit828 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Date of first compliant deposit: | 27 December 2015 | ||||||||||
| Date of first compliant Open Access: | 27 December 2015 | ||||||||||
| Funder: | Wellcome Trust (London, England) | ||||||||||
| Grant number: | 090853 (WT), 084633 (WT) |
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