Cock, Peter J. A. and Whitworth, David E.. (2010) Evolution of relative reading frame bias in unidirectional prokaryotic gene overlaps. Molecular Biology and Evolution, Vol.27 (No.4). pp. 753-756. ISSN 0737-4038

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Abstract

Pairs of unidirectional (same strand) genes can overlap in one of two phases (relative reading frames). There is a striking bias in the relative abundance of prokaryotic gene overlaps in the two possible phases. A simple model is presented based on unidirectional gene overlaps evolving from nonoverlapping gene pairs, through the adoption of alternative start codons by the downstream genes. Potential alternative start codons within upstream gene sequences were found to occur at greater frequencies in one phase, corresponding to the most prevalent phase of gene overlaps. We therefore suggest that the phase bias of overlapping genes is primarily a consequence of the N-terminal extension of downstream genes through adoption of new start codons.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC)
Journal or Publication Title:	Molecular Biology and Evolution
Publisher:	Oxford University Press
ISSN:	0737-4038
Date:	April 2010
Volume:	Vol.27
Number:	No.4
Number of Pages:	4
Page Range:	pp. 753-756
Identification Number:	10.1093/molbev/msp302
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), University of Warwick. MOAC Doctoral Training Centre
URI:	http://wrap.warwick.ac.uk/id/eprint/6068

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