A variant in LIN288 is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure
Medland, Sarah E., Zayats, Tetyana, Glaser, Beate, Nyholt, Dale R., Gordon, Scott D., Wright, Margaret J., Montgomery, Grant W., Campbell, Megan J., Henders, Anjali K., Timpson, Nicholas J., Peltonen, Leena, Wolke, Dieter, Ring, Susan M., Deloukas, Panos, Martin, Nicholas G., Smith, George Davey and Evans, David M.. (2010) A variant in LIN288 is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure. American Journal of Human Genetics, Vol.86 (No.4). pp. 519-525. ISSN 0002-9297Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ajhg.2010.02.017
The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 20:40, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 x 10(-8)) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 x 10(-6)). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 20:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH426 Genetics|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||American Journal of Human Genetics|
|Date:||9 April 2010|
|Number of Pages:||7|
|Page Range:||pp. 519-525|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||UK Medical Research Council, Wellcome Trust, University of Bristol, MRC, Australian National Health and Medical Research Council (NHMRC), Australian Research Council, Netherlands Scientific Organization (NWO)|
|Grant number:||MRC 90600705, MRC G0800582, 241944, 339462, 389927, 389875, 389891, 389892, 389938, 443036, 442915, 442981, 496739, 552485, 552498, A7960034, A79906588, A79801419, DP0212016, DP0343921, 480-05-003|
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