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Identification of horizontally acquired DNA using genome signature analysis
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Jarvis, Stephen A., Mirsky, Jason S., Peden, John F. and Saunders, Nigel J. (2000) Identification of horizontally acquired DNA using genome signature analysis. University of Warwick. Department of Computer Science. (Department of Computer Science research report). (Unpublished)
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Abstract
Identification of regions with untypical percentage G+C composition and dinucleotide signatures are two genome analysis techniques used in the identification of horizontally acquired DNA. We describe a generic program framework for performing both types of analysis in linear time. The approach is extended for length >2 oligonucleotide signatures. Using the derived program we test some of the conclusions of Karlin and Burge, the primary exponents of these techniques. We demonstrate that no single method of signature analysis is sufficient for the complete identification of horizontally acquired DNA. Consequently we produce a fast program - and a robust methodology - for the production and employment genome signatures in the identification of horizontally acquired DNA.
Item Type: | Report | ||||
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Subjects: | Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||
Library of Congress Subject Headings (LCSH): | DNA fingerprinting | ||||
Series Name: | Department of Computer Science research report | ||||
Publisher: | University of Warwick. Department of Computer Science | ||||
Official Date: | 1 September 2000 | ||||
Dates: |
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Number: | Number 379 | ||||
Number of Pages: | 13 | ||||
DOI: | CS-RR-379 | ||||
Institution: | University of Warwick | ||||
Theses Department: | Department of Computer Science | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Unpublished | ||||
Funder: | Wellcome Trust (London, England) | ||||
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