Jarvis, Stephen A., Mirsky, Jason S., Peden, John F. and Saunders, Nigel J. (2000) Identification of horizontally acquired DNA using genome signature analysis. University of Warwick. Department of Computer Science. (Department of Computer Science research report). (Unpublished)

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Abstract

Identification of regions with untypical percentage G+C composition and dinucleotide signatures are two genome analysis techniques used in the identification of horizontally acquired DNA. We describe a generic program framework for performing both types of analysis in linear time. The approach is extended for length >2 oligonucleotide signatures. Using the derived program we test some of the conclusions of Karlin and Burge, the primary exponents of these techniques. We demonstrate that no single method of signature analysis is sufficient for the complete identification of horizontally acquired DNA. Consequently we produce a fast program - and a robust methodology - for the production and employment genome signatures in the identification of horizontally acquired DNA.

Item Type:	Report
Subjects:	Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software
Divisions:	Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH):	DNA fingerprinting
Series Name:	Department of Computer Science research report
Publisher:	University of Warwick. Department of Computer Science
Official Date:	1 September 2000
Dates:	Date Event 1 September 2000 Published
Number:	Number 379
Number of Pages:	13
DOI:	CS-RR-379
Institution:	University of Warwick
Theses Department:	Department of Computer Science
Status:	Not Peer Reviewed
Publication Status:	Unpublished
Funder:	Wellcome Trust (London, England)
Related URLs:	Organisation

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