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Diurnal variation is lost in preterm deliveries before 28 weeks of gestation

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Vatish, Manu, Steer, P. J., Blanks, Andrew M., Hong, M. and Thornton, Steven. (2010) Diurnal variation is lost in preterm deliveries before 28 weeks of gestation. BJOG - An International Journal of Obstetrics & Gynaecology, Vol.117 (No.6). pp. 765-767. ISSN 1470-0328

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Official URL: http://dx.doi.org/10.1111/j.1471-0528.2010.02526.x

Abstract

Preterm delivery is the primary cause of neonatal mortality and morbidity worldwide. Labour at term occurs as a culmination of maturational events in both the fetus and maternal uterus. This process exhibits diurnal variation, with the onset of labour being more common at night. We have confirmed that this diurnal variation is present in gestations between 28 and 36 weeks, but is absent below 28 weeks. We hypothesise that this is because before 28 weeks of gestation, the onset of labour may result from a pathological rather than a physiological process. This may have important implications regarding any pharmacological approach to the prevention and/or treatment of very early preterm labour.

Item Type:

Journal Article

Subjects:

R Medicine > RG Gynecology and obstetrics

Divisions:

Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Reproductive Health
Faculty of Medicine > Warwick Medical School

Journal or Publication Title:

BJOG - An International Journal of Obstetrics & Gynaecology

Publisher:

Wiley-Blackwell Publishing Ltd.

ISSN:

1470-0328