Laclaustra, Martin, Navas-Acien, Ana, Stranges, Saverio, Ordovas, J. M. and Guallar, Eliseo. (2009) Serum selenium concentrations and hypertension in the US population. Circulation: Cardiovascular Quality and Outcomes, Vol.2 (No.4). pp. 369-376. ISSN 1941-7713

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Abstract

Background - Selenium is an antioxidant micronutrient with potential interest for cardiovascular disease prevention. Few studies have evaluated the association between selenium and hypertension, with inconsistent findings. We explored the relationship of serum selenium concentrations with blood pressure and hypertension in a representative sample of the US population. Methods and Results - We undertook a cross-sectional analysis of 2638 adults >= 40 years old who participated in the 2003 to 2004 National Health and Nutrition Examination Survey. Serum selenium was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry. Hypertension was defined as blood pressure >= 140/90 mm Hg or current use of antihypertensive medication. Mean serum selenium was 137.1 mu g/L. The multivariable adjusted ;differences (95% CIs) in blood pressure levels comparing the highest (>= 150 mu g/L) to the lowest (<122 mu g/L) quintile of serum selenium were 4.3 (1.3 to 7.4), 1.6 (-0.5 to 3.7), and 2.8 (0.8 to 4.7) mm Hg for systolic, diastolic, and pulse pressure, respectively. The corresponding odds ratio for hypertension was 1.73 (1.18 to 2.53). In spline regression models, blood pressure levels and the prevalence of hypertension increased with increasing selenium concentrations up to 160 mu g/L. Conclusions - High serum selenium concentrations were associated with higher prevalence of hypertension. These findings call for a thorough evaluation of the risks and benefits associated with high selenium status in the United States. (Circ Cardiovasc Qual Outcomes. 2009;2:369-376.)

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Selenium -- Physiological effect -- Research, Blood lipids, Hypertension -- Pathogenesis, Nutrition, National Health and Nutrition Examination Survey (U.S.), Selenium -- Analysis -- United States -- Statistics, Selenium in human nutrition -- Analysis -- United States -- Statistics
Journal or Publication Title:	Circulation: Cardiovascular Quality and Outcomes
Publisher:	Lippincott Williams & Wilkins
ISSN:	1941-7713
Date:	July 2009
Volume:	Vol.2
Number:	No.4
Number of Pages:	8
Page Range:	pp. 369-376
Identification Number:	10.1161/CIRCOUTCOMES.108.831552
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institute of Environmental Health Sciences (NIEHS), American Heart Association (AHA)
Grant number:	1 R01 ES012673 (NIEHS), 0230232N (AHA)
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URI:	http://wrap.warwick.ac.uk/id/eprint/6169

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