Agoti, Charles N., Otieno, James R., Gitahi, Caroline W., Cane, Patricia and Nokes, D. James (2014) Rapid spread and diversification of respiratory syncytial virus genotype ON1, Kenya. Emerging Infectious Diseases , Volume 20 (Number 6). pp. 950-959. doi:10.3201/eid2006.131438

Research output not available from this repository, contact author.

Request Changes to record.

Abstract

Respiratory syncytial virus genotype ON1, which is characterized by a 72-nt duplication in the attachment protein gene, has been detected in >10 countries since first identified in Ontario, Canada, in 2010. We describe 2 waves of genotype ON1 infections among children admitted to a rural hospital in Kenya during 2012. Phylogenetic analysis of attachment protein gene sequences showed multiple introductions of genotype ON1; variants distinct from the original Canadian viruses predominated in both infection waves. The genotype ON1 dominated over the other group A genotypes during the second wave, and some first wave ON1 variants reappeared in the second wave. An analysis of global genotype ON1 sequences determined that this genotype has become considerably diversified and has acquired signature coding mutations within immunogenic regions, and its most recent common ancestor dates to ≈2008–2009. Surveillance of genotype ON1 contributes to an understanding of the mechanisms of rapid emergence of respiratory viruses.

Item Type:	Journal Article
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Emerging Infectious Diseases
Publisher:	US Department of Health and Human Services
ISSN:	1080-6059
Official Date:	June 2014
Dates:	Date Event June 2014 Published
Volume:	Volume 20
Number:	Number 6
Page Range:	pp. 950-959
DOI:	10.3201/eid2006.131438
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item