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De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex

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Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505

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Official URL: http://dx.doi.org/10.1002/anie.201307505

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Abstract

Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N3)2(OH)2(MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Photochemistry, Antineoplastic agents, Platinum -- Therapeutic use
Journal or Publication Title: Angewandte Chemie International Edition
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 1433-7851
Official Date: 16 December 2013
Dates:
DateEvent
16 December 2013Published
25 August 2013Available
UNSPECIFIEDAccepted
26 August 2013Submitted
Volume: Volume 52
Number: Number 51
Page Range: pp. 13633-13637
DOI: 10.1002/anie.201307505
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: University of Warwick, Overseas Research Students Awards Scheme (ORSAS), Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), Birmingham Science City, Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC)
Grant number: EP/G006792/1 (EPSRC), 247450 (ERC), 21020102039 (NSFC)

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