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De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex
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Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505
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Official URL: http://dx.doi.org/10.1002/anie.201307505
Abstract
Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N3)2(OH)2(MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science > Chemistry | ||||||||||
| Library of Congress Subject Headings (LCSH): | Photochemistry, Antineoplastic agents, Platinum -- Therapeutic use | ||||||||||
| Journal or Publication Title: | Angewandte Chemie International Edition | ||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||||
| ISSN: | 1433-7851 | ||||||||||
| Official Date: | 16 December 2013 | ||||||||||
| Dates: |
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| Volume: | Volume 52 | ||||||||||
| Number: | Number 51 | ||||||||||
| Page Range: | pp. 13633-13637 | ||||||||||
| DOI: | 10.1002/anie.201307505 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | University of Warwick, Overseas Research Students Awards Scheme (ORSAS), Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), Birmingham Science City, Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC) | ||||||||||
| Grant number: | EP/G006792/1 (EPSRC), 247450 (ERC), 21020102039 (NSFC) |
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