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Ice recrystallisation inhibition by polyols : comparison of molecular and macromolecular inhibitors and role of hydrophobic units
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Deller, Robert C., Congdon, Thomas R., Sahid, Mohammed A., Morgan, Michael, Vatish, Manu, Mitchell, Daniel A., Notman, Rebecca and Gibson, Matthew I. (2013) Ice recrystallisation inhibition by polyols : comparison of molecular and macromolecular inhibitors and role of hydrophobic units. Biomaterials Science, Volume 1 (Number 5). pp. 478-485. doi:10.1039/c3bm00194f ISSN 2047-4830.
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Official URL: http://dx.doi.org/10.1039/C3BM00194F
Abstract
The ability of polyols to act as ice recrystallisation inhibitors (IRI), inspired by antifreeze (glyco)proteins are studied. Poly(vinyl alcohol), PVA, a known IRI active polymer was compared to a panel of mono and polysaccharides, with the aim of elucidating why some polyols are active and others show no activity. When corrected for total hydroxyl concentration all the carbohydrate-based polyols displayed near identical activity with no significant influence of molecular weight. Conversely, PVA was several orders of magnitude more active and its activity displays significant dependence on molecular-weight implying that its mechanism of action is not identical to that of carbohydrates. In a second step, the role of hydrophobicity was studied and it is observed that monosaccharide IRI activity is enhanced by alkylation. Dye-quenching assays demonstrated that PVA is able to present a hydrophobic surface without self-aggregation. Therefore, the ability to present a hydrophobic domain is hypothesised to be essential to obtain high IRI activity, which has many biotechnological applications.
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biomaterials Science | ||||||||||
| Publisher: | R S C Publications | ||||||||||
| ISSN: | 2047-4830 | ||||||||||
| Official Date: | 2013 | ||||||||||
| Dates: |
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| Volume: | Volume 1 | ||||||||||
| Number: | Number 5 | ||||||||||
| Page Range: | pp. 478-485 | ||||||||||
| DOI: | 10.1039/c3bm00194f | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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