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Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis
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Parker, Johanna, Hashmi, Omar, Dutton, David, Mavrodaris, Angelique, Stranges, Saverio, Kandala, Ngianga-Bakwin, Clarke, Aileen and Franco, Oscar H. (2010) Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas, Vol.65 (No.3). pp. 225-236. doi:10.1016/j.maturitas.2009.12.013
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Official URL: http://dx.doi.org/10.1016/j.maturitas.2009.12.013
Abstract
Cardiometabolic disorders and vitamin D deficiency are becoming increasingly more prevalent across multiple populations. Different studies have suggested a potential association between abnormal vitamin D levels and multiple pathological conditions including cardiovascular diseases and diabetes.
We aimed to evaluate the association between vitamin D levels, using 25-hydroxy vitamin D (25OHD) as an indicator of vitamin D status, and the presence of cardiometabolic disorders including cardiovascular disease, diabetes and metabolic syndrome.
We performed a systematic review of the current literature on vitamin D and cardiometabolic disorders using the PubMed and Web of Knowledge databases in September 2009. Studies in adults looking at the effect of vitamin D levels on outcomes relating to cardiometabolic disorders were selected. We performed a mesa-analysis to assess the risk of developing cardiometabolic disorders comparing the highest and lowest groups of serum 25OHD.
From 6130 references we identified 28 studies that met our inclusion criteria, including 99,745 participants. There was moderate variation between the studies in their grouping of 25OHD levels, design and analytical approach. We found that the highest levels of serum 25OHD were associated with a 43% reduction in cardiometabolic disorders [OR 0.57,95% (CI 0.48-0.68)]. Similar levels were observed, irrespective of the individual cardiometabolic outcome evaluated or study design. High levels of vitamin D among middle-age and elderly populations are associated with a substantial decrease in cardiovascular disease, type 2 diabetes and metabolic syndrome. If the relationship proves to be causal, interventions targeting vitamin D deficiency in adult populations could potentially slow the current epidemics of cardiometabolic disorders. (C) 2009 Elsevier Ireland Ltd. All rights reserved
| Item Type: | Journal Item | ||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) > Warwick Evidence Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Vitamin D in the body, Vitamin D deficiency, Cardiovascular system -- Diseases -- Research, Diabetes -- Research, Metabolic syndrome, Systematic reviews (Medical research) | ||||
| Journal or Publication Title: | Maturitas | ||||
| Publisher: | Elsevier Ireland Ltd | ||||
| ISSN: | 0378-5122 | ||||
| Official Date: | March 2010 | ||||
| Dates: |
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| Volume: | Vol.65 | ||||
| Number: | No.3 | ||||
| Number of Pages: | 12 | ||||
| Page Range: | pp. 225-236 | ||||
| DOI: | 10.1016/j.maturitas.2009.12.013 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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